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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	aspartame
Molecular formula	C14H18N2O5
IUPAC name	(3S)-3-amino-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight	294.307
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-2.7
Synonyms	SW219179-1 Tox21_302965 Methyl L-aspartyl-L-phenylalanine Asp-Phe methyl ester N-L-ALPHA-ASPARTYL L-PHENYLALANINE 1-METHYL ESTER ASPARTAME (SEE ALSO (TRANSGENIC MODEL EVALUATION II (ASPARTAME)) NCGC00091104-05 Aspartamo [INN-Spanish] OR350295 C11045 SC 18862 CS-2418 Spectrum3_001949 DSSTox_RID_75371 (3S)-3-amino-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid H-Asp-Phe-OMe 22839-47-0 Jsp004609 AB00376622_08 L-Aspartyl-L-phenylalanyl methyl ester AK-47609 TC-308713 Z0H242BBR1 MLS001066421 Asp-phe-ome N-L-alpha-Aspartyl-L-phenylalanineMethylEster Aspartame, European Pharmacopoeia (EP) Reference Standard NCGC00256407-01 aspartyl-phenylalanine methyl ester Pharmakon1600-01505306 CCG-39444 SCHEMBL3636 E951 (S)-3-amino-4-((S)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)-4-oxobutanoic acid HMS2233D15 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid L-Aspartyl-L-3-phenylalanine methyl ester AB2000441 M-4739 alpha-L-Aspartyl-L-Phenylalanine Methyl Ester ST24032106 Tox21_111459 APM;Canderel;L-alpha-aspartyl-L-phenylalanine-methylester;(S)-3-Amino-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid N-(L-a-Aspartyl)-L-phenylalanine methyl ester NCGC00091104-03 Aspartame, United States Pharmacopeia (USP) Reference Standard NSC758953 BRD-K78841970-001-06-2 SBB006713 SPECTRUM1505306 DSSTox_CID_107 FT-0627714 1-Methyl N-L-alpha-aspartyl-L-phenylalanine IAOZJIPTCAWIRG-QWRGUYRKSA-N 7421-84-3 L-Aspartyl-L-phenylalanine methyl ester, 96% AC1Q41IK Methyl L-alpha-aspartyl-L-phenylalanate Sweet dipeptide TRANSGENIC MODEL EVALUATION II (ASPARTAME) Methyl N-L-alpha-aspartyl-L-phenylalaninate Asp-Phe methyl ester, >=98% N-L-alpha-Aspartyl-L-phenylalanine 1-methyl ester Aspartame [USAN:INN:BAN:NF] NCGC00095160-01 Aspartamum Pal Sweet Canderel SC-17477 D00MFA SR-05000001682 DTXSID0020107 (3S)-3-{N-[(1S)-1-(methoxycarbonyl)-2-phenylethyl]carbamoyl}-3-aminopropanoic acid HMS1922B16 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester KBio3_002839 AB00376622_09 L-Phenylalanine, L-alpha-aspartyl-, 2-methyl ester AKOS015920055 Tox21_111080 ZINC1532132 AM20060556 MLS001306461 Aspartam NCGC00091104-01 Aspartame, L,L-alpha- NCGC00259864-01 Aspartylphenylalanine methyl ester s2036 CCRIS 5456 SMR000471870 DB00168 EINECS 245-261-3 (S)-3-amino-n-((s)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid HSDB 3915 39A470 L-aspartyl-L-phenyl-alanine methyl ester AC-12293 MCULE-7493691716 Succinamic acid, 3-amino-N-(alpha-carboxyphenethyl)-, N-methyl ester, stereoisomer Tox21_202315 AS-13889 N-(L-alpha-Aspartyl)-L-phenylalanine methyl ester Aspartame (NF/INN) NCGC00091104-04 Aspartamo Nutrasweet BSPBio_003549 SBI-0206757.P001 CHEMBL171679 Spectrum2_001706 DSSTox_GSID_20107 (3S)-3-amino-3-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid GE0967 172964-81-7 J-502447 A0997 L-Aspartyl-L-phenylalanine methyl ester, 98% AJ-26753 methyl L-alpha-aspartyl-L-phenylalaninate SY012642 UNII-Z0H242BBR1 MFCD00002724 Asp-Phe methyl ester, >=99.0% (HPLC) N-L-alpha-Aspartyl-L-phenylalanine methyl ester Aspartame, analytical standard NCGC00095160-03 Aspartamum [INN-Latin] Palsweet Diet CAS-22839-47-0 SC-18862 D02381 E 951 (S)-3-Amino-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid HMS2093B05 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, stereoisomer KS-00000AID AB0058040 L-Phenylalanine, N-L-alpha-aspartyl-, 1-methyl ester alpha-aspartyl-phenylalanine methyl ester SR-05000001682-1 Tox21_111080_1 AM84801 MolPort-001-792-024 Aspartam [INN-French] NCGC00091104-02 Aspartame, Pharmaceutical Secondary Standard; Certified Reference Material NSC-758953 BR-47609 Sanecta CHEBI:2877 SPBio_001692 Dipeptide sweetener Epitope ID:164026 1-Methyl N-L-alpha-aspartyl-L-phenylalanate HY-B0361 53906-69-7 L-Aspartyl-L-phenylalanine methyl ester AC1L34VS Methyl aspartylphenylalanate [ Show all ]
Inchi Key	IAOZJIPTCAWIRG-QWRGUYRKSA-N
Inchi ID	InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1
PubChem CID	134601
ChEMBL	CHEMBL171679
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00168
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
128619	Taste receptor type 1 member 2	Q8TE23	TAS1R2	Homo sapiens (Human)	839
549502	Taste receptor type 1 member 3	Q7RTX0	TAS1R3	Homo sapiens (Human)	852
128618	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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