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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	fluprostenol
Molecular formula	C23H29F3O6
IUPAC name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoic acid
Molecular weight	458.474
Hydrogen bond acceptor	9
Hydrogen bond donor	4
XlogP	2.9
Synonyms	MolPort-006-128-349 SR-01000946504-1 UNII-MEH3MCE8X1 (5Z ,13E )-(9S,11R,15R )-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid 1007AH BML2-G08 D08TWE Fluprostenol [INN:BAN] HMS1989C18 NCGC00160386-04 travoprost free acid [1R-[1\|A(Z),2\|A(1E,3R*),3\|A,5\|A]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid 1771AH AC1NSJZQ CAS-40666-16-8 DSSTox_RID_81358 Fluprostenolum [INN-Latin] ICI 81,008 SCHEMBL230607 Travoprost related compound A [USP] (+)-fluprostenol (Z)-7-[(1alpha)-3alpha,5alpha-Dihydroxy-2beta-[(3R,1E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid 40666-16-8 AL-5848 CHEMBL1201379 HMS1361C18 MEH3MCE8X1 NCGC00160386-01 Tox21_111778 WWSWYXNVCBLWNZ-QIZQQNKQSA-N (5Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-(trifluoromethyl)phenoxy)-3-hydroxybut-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid 16-(m-Trifluoromethylphenoxy)-17,18,19,20-tetranorprostaglandin F2alpha 54276-17-4 BRD-K31611373-001-02-7 DSSTox_CID_26122 Fluprostenol, (+)- HMS3402C18 NCGC00160386-05 Travoprost related compound A A [3H](+)-fluprostenol (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoic acid AKOS024458212 CHEBI:60782 DTXSID7046122 GTPL1940 ICI 81008 MFCD03427566 SR-01000946504 UNII-358S7VUE5N component WWSWYXNVCBLWNZ-QIZQQNKQSA-N (+/-)-16-(3-Trifluoromethylphenoxy)tetranorprostaglandin F2alpha (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoic acid 5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-buten-1-yl)cyclopentyl)-, (5Z)- BDBM50206025 D05TNX Fluprostenol 10 mg/mL in ethanol HMS1791C18 NCGC00160386-02 travoprost acid ZINC4474587 (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 16-(m-Trifluoromethylphenoxy)-17,18,19,20-tetranorprostaglandin F2\|A 55028-71-2 (mono-hydrochloride salt) BSPBio_001336 DSSTox_GSID_46122 Fluprostenolum HMS3648H08 rac-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoic acid Travoprost related compound A RS [USP] [3H]-(+)-fluprostenol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoic acid 276F174 AL 5848 EINECS 255-029-3 GTPL3417 IDI1_033806 [ Show all ]
Inchi Key	WWSWYXNVCBLWNZ-QIZQQNKQSA-N
Inchi ID	InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
PubChem CID	5311100
ChEMBL	CHEMBL1201379
IUPHAR	1940
BindingDB	50206025
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
546363	Prostacyclin receptor	P43119	PTGIR	Homo sapiens (Human)	386
384208	Prostaglandin E2 receptor EP3 subtype	P43115	PTGER3	Homo sapiens (Human)	390
384209	Prostaglandin F2-alpha receptor	P43088	PTGFR	Homo sapiens (Human)	359
555217	Prostaglandin F2-alpha receptor	P43117	Ptgfr	Mus musculus (Mouse)	366
555216	Thromboxane A2 receptor	P21731	TBXA2R	Homo sapiens (Human)	343

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