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| Name | Pituitary adenylate cyclase-activating polypeptide type I receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | ADCYAP1R1 |
| Synonym | PACAPR1 pituitary adenylate cyclase activating polypeptide 1 receptor (1) PACAP1-R PACAP-R1 PACAP-R-1 [ Show all ] |
| Disease | N/A |
| Length | 468 |
| Amino acid sequence | MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT |
| UniProt | P41586 |
| Protein Data Bank | 3n94 |
| GPCR-HGmod model | P41586 |
| 3D structure model | This structure is from PDB ID 3n94. |
| BioLiP | BL0183307 |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL5399 |
| IUPHAR | 370 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 515 |  CID 44566179 | C205H333N63O53S | 4560.37 | 67 / 71 | -16.3 | No |
| 3771 |  [Sar4]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 67 | -17.9 | No |
| 5967 |  [Glu3]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 68 | -17.8 | No |
| 15399 |  CHEMBL255635 | C22H17ClN4O2 | 404.854 | 4 / 2 | 3.7 | Yes |
| 522145 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522168 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 23524 |  CHEMBL444343 | C26H28N2O5 | 448.519 | 6 / 2 | 5.0 | Yes |
| 23568 |  BDBM81535 | C182H300N56O45S | 4024.81 | 58 / 60 | -13.3 | No |
| 25000 |  CHEMBL404071 | C22H16ClF3N2O3 | 448.826 | 7 / 2 | 5.5 | No |
| 27210 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 32962 |  CHEMBL270785 | C21H17ClN2O3 | 380.828 | 4 / 2 | 4.6 | Yes |
| 36910 |  [Ala2]PACAP38 | C203H331N63O52S | 4518.33 | 66 / 67 | -17.1 | No |
| 38093 |  CHEMBL256636 | C22H16ClF3N2O3 | 448.826 | 7 / 2 | 5.5 | No |
| 39376 |  CID 44139716 | C141H222N40O38S | 3117.63 | 46 / 47 | -9.7 | No |
| 40121 |  CHEMBL256837 | C22H16ClF3N2O3 | 448.826 | 7 / 2 | 5.5 | No |
| 46519 |  [N-Me-Asp3]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 67 | -17.9 | No |
| 553573 |  MK 0893 | C32H27Cl2N3O4 | 588.485 | 5 / 2 | 6.8 | No |
| 65255 |  CID 44566139 | C143H226N40O39S | 3161.68 | 47 / 47 | -10.2 | No |
| 76287 |  CHEMBL409325 | C26H27ClN2O5 | 482.961 | 6 / 2 | 5.6 | No |
| 83453 |  CID 44566138 | C204H333N63O53S | 4548.36 | 67 / 71 | -16.4 | No |
| 84403 |  [N-Me-Thr7]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 67 | -17.9 | No |
| 88975 |  CID 44139713 | C139H222N38O39S | 3081.59 | 46 / 47 | -10.1 | No |
| 93902 |  CID 16214685 | C142H223N39O40S | 3148.64 | 48 / 48 | -12.0 | No |
| 524295 |  SCHEMBL2101506 | C21H20ClFN2O4 | 418.849 | 5 / 3 | 2.3 | Yes |
| 100728 |  [N-Me-Phe6]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 67 | -17.9 | No |
| 106196 |  [Cha6]PACAP38 | C203H337N63O53S | 4540.38 | 67 / 68 | -17.0 | No |
| 110567 |  CID 44566184 | C204H331N63O53S | 4546.34 | 67 / 71 | -16.7 | No |
| 119647 |  CHEMBL152640 | C28H26N4O2 | 450.542 | 4 / 2 | 5.9 | No |
| 121826 |  CHEMBL1187422 | C144H228N40O39S | 3175.71 | 47 / 48 | -9.8 | No |
| 124004 |  CID 44566171 | C144H226N40O38S | 3157.69 | 46 / 46 | -9.0 | No |
| 124005 |  CID 44139868 | C144H226N40O38S | 3157.69 | 46 / 46 | -9.0 | No |
| 124900 |  CID 44139848 | C148H228N40O39S | 3223.75 | 47 / 48 | -8.7 | No |
| 128827 |  [Glu3]PACAP27 | C143H226N40O39S | 3161.68 | 47 / 46 | -10.7 | No |
| 129522 |  CID 44566151 | C204H333N63O53S | 4548.36 | 67 / 71 | -16.7 | No |
| 131883 |  CID 44566161 | C142H224N40O40S | 3163.65 | 48 / 49 | -10.7 | No |
| 132423 |  CHEMBL1644183 | C27H20Cl2F3N3O4 | 578.369 | 8 / 2 | 6.4 | No |
| 142592 |  [Bip6]PACAP38 | C209H335N63O53S | 4610.43 | 67 / 68 | -16.5 | No |
| 152329 |  CHEMBL153038 | C26H24ClN3O2 | 445.947 | 3 / 2 | 5.9 | No |
| 164265 |  [Aib2]PACAP27 | C143H226N40O38S | 3145.68 | 46 / 45 | -9.9 | No |
| 167522 |  CID 44566159 | C142H230N40O39S | 3153.7 | 47 / 48 | -9.2 | No |
| 184136 |  [Ala1]PACAP38 | C200H329N61O53S | 4468.27 | 66 / 67 | -17.9 | No |
| 192114 |  CID 44139855 | C142H222N40O39S | 3145.64 | 47 / 47 | -10.9 | No |
| 196244 |  [Asn3]PACAP38 | C203H332N64O52S | 4533.35 | 66 / 68 | -16.5 | No |
| 197815 |  CID 44566174 | C204H333N63O52S | 4532.36 | 66 / 71 | -15.4 | No |
| 198581 |  [N-Me-Ile5]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 67 | -17.9 | No |
| 199635 |  CID 44139863 | C143H226N40O39S | 3161.68 | 47 / 47 | -10.2 | No |
| 210835 |  [Ala7]PACAP38 | C202H329N63O52S | 4504.3 | 66 / 67 | -17.5 | No |
| 211226 |  CID 44139849 | C144H226N40O39S | 3173.69 | 47 / 47 | -10.0 | No |
| 219532 |  [Ala4]PACAP38 | C204H333N63O53S | 4548.36 | 67 / 68 | -17.7 | No |
| 224322 |  CHEMBL2206397 | C14H18N2 | 214.312 | 1 / 1 | 3.6 | Yes |
| 229221 |  CID 44566137 | C143H226N40O39S | 3161.68 | 47 / 47 | -10.2 | No |
| 229606 |  Ac-PACAP27 | C144H226N40O40S | 3189.69 | 47 / 46 | -10.8 | No |
| 230947 |  CHEMBL444801 | C27H30N2O6 | 478.545 | 7 / 2 | 5.0 | Yes |
| 235422 |  [Aad3]PACAP38 | C205H335N63O53S | 4562.38 | 67 / 68 | -17.4 | No |
| 243133 |  CID 44566141 | C143H226N40O39S | 3161.68 | 47 / 47 | -10.2 | No |
| 243756 |  CID 44566181 | C143H224N40O39S | 3159.67 | 47 / 47 | -10.6 | No |
| 250442 |  CID 44566120 | C200H325N63O53S | 4492.25 | 67 / 72 | -17.9 | No |
| 252991 |  CHEMBL409729 | C24H20ClF3N2O5 | 508.878 | 9 / 2 | 5.4 | No |
| 253327 |  CHEMBL270226 | C27H29ClN2O5 | 496.988 | 6 / 2 | 6.0 | No |
| 254615 |  CHEMBL257706 | C24H22ClN3O5 | 467.906 | 6 / 3 | 3.8 | Yes |
| 257377 |  CID 44566183 | C143H224N40O39S | 3159.67 | 47 / 47 | -10.4 | No |
| 257872 |  CID 44139844 | C143H226N40O39S | 3161.68 | 47 / 47 | -10.4 | No |
| 529041 |  CHEMBL3736134 | C150H227FN40O39S | 3265.76 | 48 / 48 | -8.2 | No |
| 262915 |  CHEMBL402430 | C30H24ClN3O3 | 509.99 | 4 / 2 | 6.2 | No |
| 267421 |  Ac-PACAP38 | C205H333N63O54S | 4576.37 | 67 / 68 | -17.9 | No |
| 281910 |  CID 44566147 | C143H226N40O39S | 3161.68 | 47 / 47 | -10.2 | No |
| 291003 |  CID 44566153 | C142H225N41O38S | 3146.67 | 46 / 48 | -8.7 | No |
| 299969 |  CHEMBL255824 | C22H16ClF3N2O3 | 448.826 | 7 / 2 | 5.5 | No |
| 303056 |  CID 44566182 | C204H331N63O53S | 4546.34 | 67 / 71 | -16.8 | No |
| 308701 |  [D-Asp3]PACAP27 | C142H224N40O39S | 3147.66 | 47 / 46 | -11.1 | No |
| 308702 |  [D-Ser2]PACAP27 | C142H224N40O39S | 3147.66 | 47 / 46 | -11.1 | No |
| 308703 |  CID 44139860 | C142H224N40O39S | 3147.66 | 47 / 48 | -10.3 | No |
| 308704 |  CID 44566125 | C142H224N40O39S | 3147.66 | 47 / 48 | -10.3 | No |
| 308705 |  CID 44566133 | C142H224N40O39S | 3147.66 | 47 / 48 | -10.3 | No |
| 308706 |  PACAP 1-27 | C142H224N40O39S | 3147.66 | 47 / 48 | -10.3 | No |
| 554792 |  pituitary adenylate cyclase activating polypeptide-27 | C142H224N40O39S | 3147.66 | 47 / 48 | -10.3 | No |
| 308713 |  CID 44139861 | C142H224N40O39S | 3147.66 | 47 / 48 | -10.3 | No |
| 310725 |  CID 44566162 | C203H331N63O54S | 4550.33 | 68 / 73 | -17.0 | No |
| 317209 |  [Ala2]PACAP27 | C142H224N40O38S | 3131.66 | 46 / 45 | -10.1 | No |
| 320089 |  CHEMBL272118 | C21H17ClN2O3 | 380.828 | 4 / 2 | 4.6 | Yes |
| 320554 |  CHEMBL256880 | C23H18ClN3O2 | 403.866 | 3 / 2 | 4.8 | Yes |
| 330307 |  CHEMBL2087421 | C24H40N4O5S | 496.667 | 8 / 0 | 1.6 | Yes |
| 530922 |  CHEMBL3736230 | C150H228N40O39S | 3247.77 | 47 / 48 | -8.3 | No |
| 335803 |  CID 44566130 | C203H331N63O53S | 4534.33 | 67 / 72 | -16.6 | No |
| 335804 |  CID 44566134 | C203H331N63O53S | 4534.33 | 67 / 72 | -16.6 | No |
| 335805 |  [D-His1]PACAP38 | C203H331N63O53S | 4534.33 | 67 / 68 | -18.1 | No |
| 335806 |  [D-Ile5]PACAP38 | C203H331N63O53S | 4534.33 | 67 / 68 | -18.1 | No |
| 335807 |  [D-Ser2]PACAP38 | C203H331N63O53S | 4534.33 | 67 / 68 | -18.1 | No |
| 335808 |  AKOS024456450 | C203H331N63O53S | 4534.33 | 67 / 72 | -16.6 | No |
| 335810 |  [D-Thr7]PACAP38 | C203H331N63O53S | 4534.33 | 67 / 68 | -18.1 | No |
| 338370 |  [Ind6]PACAP27 | C142H222N40O39S | 3145.64 | 47 / 45 | -11.3 | No |
| 342302 |  CID 44139714 | C141H224N40O37S | 3103.65 | 45 / 47 | -7.2 | No |
| 342306 |  CID 44566155 | C144H228N40O39S | 3175.71 | 47 / 48 | -9.6 | No |
| 342331 |  CID 44566119 | C139H218N40O39S | 3105.57 | 47 / 48 | -11.7 | No |
| 345733 |  [N-Me-Ile5]PACAP27 | C143H226N40O39S | 3161.68 | 47 / 45 | -10.9 | No |
| 346113 |  CHEMBL270784 | C25H24ClN3O6 | 497.932 | 7 / 3 | 3.7 | Yes |
| 555041 |  BDBM81828 | C147H237N43O43S | 3326.83 | 51 / 49 | -16.6 | No |
| 353273 |  CID 44566117 | C143H226N40O39S | 3161.68 | 47 / 48 | -9.9 | No |
| 357793 |  CHEMBL269990 | C23H18ClF3N2O4 | 478.852 | 8 / 2 | 5.4 | No |
| 365400 |  [His(1-Me)1]PACAP27 | C143H226N40O39S | 3161.68 | 47 / 45 | -11.1 | No |
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