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Name | DORA-22 |
---|---|
Molecular formula | C23H22F2N4O2 |
IUPAC name | [(2R,5R)-5-[(5-fluoropyridin-2-yl)oxymethyl]-2-methylpiperidin-1-yl]-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone |
Molecular weight | 424.452 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.6 |
Synonyms | BDBM104702 SCHEMBL1716753 DORA 22 DTXSID10148765 US8569311, 1-19 [ Show all ] |
Inchi Key | ADNQCBKNFSDDHY-HZPDHXFCSA-N |
Inchi ID | InChI=1S/C23H22F2N4O2/c1-15-3-4-16(14-31-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3/t15-,16-/m1/s1 |
PubChem CID | 25126515 |
ChEMBL | CHEMBL3655675 |
IUPHAR | N/A |
BindingDB | 104702 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
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GLASS ID | Name | UniProt | Gene | Species | Length |
---|---|---|---|---|---|
2899 | Orexin receptor type 1 | P56718 | Hcrtr1 | Rattus norvegicus (Rat) | 416 |
2898 | Orexin receptor type 2 | P56719 | Hcrtr2 | Rattus norvegicus (Rat) | 460 |
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