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| Name | Orexin receptor type 1 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Hcrtr1 |
| Synonym | hypocretin (orexin) receptor 1 hypocretin receptor 1 Hypocretin receptor type 1 Hctr1 orexin receptor type 1 [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 416 |
| Amino acid sequence | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS |
| UniProt | P56718 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL1075232 |
| IUPHAR | 321 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 517319 |  CHEMBL3663396 | C25H26N2O3 | 402.494 | 4 / 0 | 4.9 | Yes |
| 2899 |  DORA-22 | C23H22F2N4O2 | 424.452 | 7 / 0 | 3.6 | Yes |
| 557479 |  SCHEMBL16031595 | C21H24F3N3O2 | 407.437 | 7 / 1 | 4.5 | Yes |
| 463688 |  CHEMBL3704949 | C21H24F3N3O2 | 407.437 | 7 / 1 | 4.5 | Yes |
| 547970 |  CHEMBL3893886 | C21H24F3N3O2 | 407.437 | 7 / 1 | 4.5 | Yes |
| 517372 |  CHEMBL3663428 | C23H20F2N4O2 | 422.436 | 7 / 0 | 3.5 | Yes |
| 517373 |  CHEMBL3663490 | C21H19F3N6O | 428.419 | 8 / 1 | 4.0 | Yes |
| 517375 |  CHEMBL3663517 | C20H19F3N8O | 444.422 | 10 / 1 | 3.0 | Yes |
| 517380 |  CHEMBL3663420 | C21H19F2N5O2 | 411.413 | 7 / 0 | 3.5 | Yes |
| 11851 |  SCHEMBL7907941 | C24H23N5O2 | 413.481 | 5 / 0 | 4.5 | Yes |
| 517384 |  CHEMBL3659204 | C24H21FN6O2 | 444.47 | 7 / 0 | 3.8 | Yes |
| 517385 |  CHEMBL3663429 | C22H22FN5O2 | 407.449 | 6 / 0 | 3.8 | Yes |
| 517391 |  CHEMBL3663548 | C22H18F4N6O | 458.421 | 10 / 1 | 2.6 | Yes |
| 517400 |  CHEMBL3659219 | C21H24BrN3O3 | 446.345 | 5 / 0 | 4.0 | Yes |
| 517402 |  CHEMBL3663426 | C24H23FN4O2 | 418.472 | 6 / 0 | 3.7 | Yes |
| 517404 |  CHEMBL3663383 | C22H24N4O2 | 376.46 | 4 / 0 | 4.3 | Yes |
| 517405 |  CHEMBL3663546 | C22H18F4N6O | 458.421 | 10 / 1 | 2.7 | Yes |
| 536407 |  CHEMBL3905361 | C20H21F3N8O | 446.438 | 10 / 1 | 2.8 | Yes |
| 465005 |  CHEMBL3691823 | C23H18F4N4O2 | 458.417 | 9 / 0 | 3.9 | Yes |
| 517414 |  CHEMBL3663509 | C20H20N6O | 360.421 | 5 / 1 | 3.1 | Yes |
| 517415 |  CHEMBL3659242 | C24H22N6O2 | 426.48 | 6 / 0 | 3.9 | Yes |
| 465042 |  CHEMBL3669051 | C20H20F3N7O2 | 447.422 | 10 / 0 | 3.2 | Yes |
| 517423 |  CHEMBL3663478 | C20H19F3N8O | 444.422 | 10 / 1 | 2.6 | Yes |
| 18521 |  SCHEMBL1717163 | C21H22FN3O2 | 367.424 | 4 / 1 | 3.7 | Yes |
| 517428 |  CHEMBL3663496 | C21H23N7O | 389.463 | 6 / 1 | 3.3 | Yes |
| 517429 |  CHEMBL3663538 | C21H18F4N6O2 | 462.409 | 11 / 1 | 3.4 | No |
| 548122 |  CHEMBL3896726 | C23H19F4N5O | 457.433 | 9 / 1 | 4.1 | Yes |
| 557921 |  SCHEMBL16040151 | C23H19F4N5O | 457.433 | 9 / 1 | 4.1 | Yes |
| 517434 |  CHEMBL3663486 | C23H19F4N5O | 457.433 | 9 / 1 | 4.1 | Yes |
| 517438 |  CHEMBL3663415 | C22H22FN5O2 | 407.449 | 6 / 0 | 3.8 | Yes |
| 517440 |  CHEMBL3663519 | C22H20F3N7O | 455.445 | 10 / 1 | 3.0 | Yes |
| 517444 |  CHEMBL3659226 | C21H22N6O2 | 390.447 | 6 / 0 | 2.6 | Yes |
| 517445 |  CHEMBL3663526 | C21H20F3N7O2 | 459.433 | 10 / 1 | 2.9 | Yes |
| 465827 |  CHEMBL3691837 | C21H18F3N3O2 | 401.389 | 6 / 1 | 4.0 | Yes |
| 466249 |  CHEMBL3704970 | C25H25N7O | 439.523 | 6 / 1 | 4.3 | Yes |
| 548185 |  CHEMBL3951401 | C25H25N7O | 439.523 | 6 / 1 | 4.3 | Yes |
| 558091 |  SCHEMBL16032036 | C25H25N7O | 439.523 | 6 / 1 | 4.3 | Yes |
| 517464 |  CHEMBL3663554 | C23H19BrFN7O | 508.355 | 7 / 1 | 4.1 | No |
| 517468 |  CHEMBL3663502 | C25H23N7O | 437.507 | 7 / 1 | 3.1 | Yes |
| 517490 |  CHEMBL3663520 | C20H20FN7O | 393.426 | 7 / 1 | 2.9 | Yes |
| 34093 |  SCHEMBL7917696 | C24H22FN5O2 | 431.471 | 6 / 0 | 4.4 | Yes |
| 467880 |  CHEMBL3669032 | C24H24N6O2 | 428.496 | 7 / 1 | 3.8 | Yes |
| 517520 |  CHEMBL3663418 | C21H21FN6O3 | 424.436 | 8 / 0 | 3.0 | Yes |
| 40739 |  Orexin receptor antagonist 10 | C19H18N6O2S | 394.453 | 7 / 0 | 3.0 | Yes |
| 40790 |  SCHEMBL2341479 | C24H27FN4O2 | 422.504 | 5 / 0 | 5.0 | Yes |
| 468000 |  CHEMBL3669026 | C22H23N7O2 | 417.473 | 7 / 1 | 3.9 | Yes |
| 468329 |  CHEMBL3691851 | C23H19F4N5O | 457.433 | 9 / 1 | 3.9 | Yes |
| 468376 |  CHEMBL3691807 | C20H18F3N7O2 | 445.406 | 10 / 0 | 2.5 | Yes |
| 517554 |  CHEMBL3663562 | C22H21FN6O | 404.449 | 7 / 1 | 2.5 | Yes |
| 517565 |  CHEMBL3663499 | C23H22N8O | 426.484 | 7 / 1 | 3.1 | Yes |
| 517569 |  CHEMBL3663408 | C22H26FN5O2 | 411.481 | 7 / 0 | 3.0 | Yes |
| 469059 |  CHEMBL3691824 | C21H18F3N5O2 | 429.403 | 8 / 0 | 3.0 | Yes |
| 469101 |  CHEMBL3691834 | C23H21F3N4O3 | 458.441 | 8 / 1 | 3.8 | Yes |
| 517586 |  CHEMBL3663549 | C22H18F4N6O | 458.421 | 10 / 1 | 2.6 | Yes |
| 469385 |  CHEMBL3691806 | C20H17F3N6O2 | 430.391 | 9 / 0 | 2.8 | Yes |
| 469815 |  CHEMBL3669048 | C20H20F3N7O2 | 447.422 | 10 / 0 | 3.1 | Yes |
| 56027 |  Orexin receptor antagonist 31 | C21H19N5O2S | 405.476 | 7 / 0 | 3.0 | Yes |
| 517615 |  CHEMBL3663413 | C22H22FN5O3 | 423.448 | 7 / 0 | 3.4 | Yes |
| 59060 |  Orexin receptor antagonist 17 | C21H21N7O3 | 419.445 | 8 / 0 | 2.6 | Yes |
| 470476 |  CHEMBL3691825 | C21H19F3N6O2 | 444.418 | 9 / 0 | 3.5 | Yes |
| 470669 |  CHEMBL3704939 | C21H22F3N7O | 445.45 | 9 / 1 | 3.8 | Yes |
| 517644 |  CHEMBL3659221 | C20H21N7O2 | 391.435 | 7 / 0 | 2.0 | Yes |
| 470776 |  CHEMBL3691850 | C21H18F4N6O | 446.41 | 9 / 1 | 3.9 | Yes |
| 537621 |  CHEMBL3977337 | C24H25N3O3 | 403.482 | 5 / 0 | 4.2 | Yes |
| 517662 |  CHEMBL3663390 | C24H25N3O3 | 403.482 | 5 / 0 | 4.2 | Yes |
| 471320 |  CHEMBL3691815 | C24H21F3N4O3 | 470.452 | 9 / 0 | 3.8 | Yes |
| 471482 |  CHEMBL3691847 | C21H20F3N7O | 443.434 | 9 / 1 | 3.5 | Yes |
| 471549 |  CHEMBL3704956 | C21H24N6O | 376.464 | 5 / 1 | 3.7 | Yes |
| 70136 |  Orexin receptor antagonist 34 | C23H20FN5O2 | 417.444 | 7 / 0 | 3.1 | Yes |
| 471609 |  CHEMBL3669041 | C20H22BrN7O | 456.348 | 6 / 1 | 3.6 | Yes |
| 72667 |  Orexin receptor antagonist 3 | C22H21N5O3 | 403.442 | 7 / 0 | 3.3 | Yes |
| 471895 |  CHEMBL3691840 | C22H18BrFN4O2 | 469.314 | 6 / 0 | 3.7 | Yes |
| 537846 |  CHEMBL3973097 | C21H17F2N5O2 | 409.397 | 7 / 1 | 3.3 | Yes |
| 472425 |  CHEMBL3691852 | C20H18F3N7O | 429.407 | 9 / 1 | 2.8 | Yes |
| 517712 |  CHEMBL3663459 | C19H20N4O2S | 368.455 | 5 / 0 | 4.0 | Yes |
| 517717 |  CHEMBL3663407 | C21H20FN5O3 | 409.421 | 8 / 0 | 2.5 | Yes |
| 472662 |  CHEMBL3704958 | C23H23N7O | 413.485 | 6 / 1 | 4.0 | Yes |
| 517720 |  CHEMBL3663527 | C22H18F4N6O | 458.421 | 10 / 1 | 3.0 | Yes |
| 517724 |  CHEMBL3663551 | C22H18F4N6O | 458.421 | 10 / 1 | 3.0 | Yes |
| 472956 |  CHEMBL3691827 | C20H17F3N6O2 | 430.391 | 9 / 0 | 3.1 | Yes |
| 559871 |  US9475819, 10A | C22H22FN5O2 | 407.449 | 6 / 0 | 3.8 | Yes |
| 517738 |  CHEMBL3659180 | C22H22FN5O2 | 407.449 | 6 / 0 | 3.8 | Yes |
| 538043 |  US9475819, 10A | C22H22FN5O2 | 407.449 | 6 / 0 | 3.8 | Yes |
| 83215 |  Orexin receptor antagonist 1 | C21H20N6O2 | 388.431 | 6 / 0 | 3.0 | Yes |
| 517744 |  CHEMBL3663573 | C24H25F3N6O2 | 486.499 | 9 / 1 | 3.3 | Yes |
| 473547 |  CHEMBL3669039 | C20H19F4N7O | 449.414 | 10 / 1 | 3.2 | Yes |
| 473622 |  CHEMBL3691826 | C21H19F3N6O2 | 444.418 | 9 / 0 | 3.5 | Yes |
| 473649 |  CHEMBL3669050 | C20H19F3N6O2 | 432.407 | 9 / 0 | 3.5 | Yes |
| 517774 |  CHEMBL3663529 | C21H20F3N7O | 443.434 | 9 / 1 | 3.3 | Yes |
| 517780 |  CHEMBL3659238 | C22H22FN5O2 | 407.449 | 6 / 0 | 3.1 | Yes |
| 89453 |  SCHEMBL1716434 | C24H25FN4O2 | 420.488 | 6 / 0 | 3.5 | Yes |
| 517799 |  CHEMBL3663458 | C21H25N3O3 | 367.449 | 5 / 0 | 3.3 | Yes |
| 517804 |  CHEMBL3663395 | C23H23N3O3 | 389.455 | 5 / 0 | 3.6 | Yes |
| 93149 |  Orexin receptor antagonist 6 | C21H19FN6O2 | 406.421 | 7 / 0 | 3.1 | Yes |
| 474832 |  CHEMBL3640038 | C20H23N7O | 377.452 | 6 / 1 | 3.0 | Yes |
| 517829 |  CHEMBL3663484 | C21H20F3N7O | 443.434 | 9 / 1 | 3.1 | Yes |
| 475018 |  CHEMBL3669024 | C20H21F3N8O | 446.438 | 10 / 1 | 3.2 | Yes |
| 517843 |  CHEMBL3663406 | C22H22FN5O3 | 423.448 | 8 / 0 | 2.9 | Yes |
| 517847 |  CHEMBL3659243 | C24H25N3O3 | 403.482 | 5 / 0 | 3.9 | Yes |
| 475456 |  CHEMBL3691843 | C20H19BrN6O2 | 455.316 | 6 / 0 | 3.3 | Yes |
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