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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	SB-649868
Molecular formula	C26H24FN3O3S
IUPAC name	N-[[(2S)-1-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]piperidin-2-yl]methyl]-1-benzofuran-4-carboxamide
Molecular weight	477.554
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	5.2
Synonyms	GTPL4461 SB649868 (S)-N-((1-(5-(4-Fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide N-[[(2S)-1-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]piperidin-2-yl]methyl]-1-benzofuran-4-carboxamide UNII-1L1V1K2M4V 4-Benzofurancarboxamide, N-(((2S)-1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)- D06CKX AKOS027323765 GSK-649868 HY-10806 SB649868; GSK649868 1L1V1K2M4V CHEMBL1272307 SB 649868 DTXSID90191491 GSK649868 SB19110 BDBM50417257 N-((1-((5-(4-Fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide SCHEMBL8045969 380899-24-1 CS-7584 SB-649,868 EX-A2570 [ Show all ]
Inchi Key	ZJXIUGNEAIHSBI-IBGZPJMESA-N
Inchi ID	InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-8-10-18(27)11-9-17)26(32)30-13-3-2-5-19(30)15-28-25(31)21-6-4-7-22-20(21)12-14-33-22/h4,6-12,14,19H,2-3,5,13,15H2,1H3,(H,28,31)/t19-/m0/s1
PubChem CID	25195495
ChEMBL	CHEMBL1272307
IUPHAR	4461
BindingDB	50417257
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
430287	Orexin receptor type 1	O43613	HCRTR1	Homo sapiens (Human)	425
430288	Orexin receptor type 1	P56718	Hcrtr1	Rattus norvegicus (Rat)	416
430286	Orexin receptor type 2	O43614	HCRTR2	Homo sapiens (Human)	444
430289	Orexin receptor type 2	P56719	Hcrtr2	Rattus norvegicus (Rat)	460

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