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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	histamine
Molecular formula	C5H9N3
IUPAC name	2-(1H-imidazol-5-yl)ethanamine
Molecular weight	111.148
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	-0.7
Synonyms	NCGC00015513-04 NCGC00093371-02 GTPL1247 NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine, 97% SCHEMBL2279 Histaminum (TN) Spectrum5_000796 I05-0627 UNII-820484N8I3 J-505349 KBio2_005593 KBioSS_001325 MCULE-4970362785 CCRIS 6535 2631-EP2298772A1 D08040 2631-EP2305668A1 EINECS 200-100-6 2631-EP2314587A1 4-Imidazoleethylamine 820484N8I3 2-(1H-Imidazol-4-yl)-ethylamine AJ-70500 2-(3H-imidazol-4-yl)ethanamine BB 0241907 2631-EP2268638A1 beta-aminothethylglyoxaline 2631-EP2277568A2 BP-11484 2631-EP2287166A2 NCGC00015513-07 F2173-0575 NCGC00093371-05 Racemic histamine Histamine, base, >=97.0% (NT) SMR000059091 HMS1792G19 STK346752 Imidazole, 4-(2-aminoethyl)- ZERO/004089 KBio1_000308 KBio3_000854 L-histamine MolPort-001-785-597 2631-EP2292620A2 CHEMBL90 2631-EP2301937A1 DivK1c_000308 2631-EP2311801A1 Ergotidine 2631-EP2316831A1 .beta.-Aminoethylglyoxaline 51-45-6 163355-EP2284166A1 AB00053481_21 2-(1H-Imidazol-4-yl)ethanamine # ALBB-005968 2-(4-Imidazolyl)ethylamine BCBcMAP01_000250 2631-EP2270002A1 Bio1_000976 2631-EP2277848A1 BSPBio_002124 NCGC00015513-02 NCGC00015513-10 FT-0627839 NSC-33792 Histamine Dihydrochloride (Salt/Mix) SBB012708 Histamine, Vetec(TM) reagent grade, >=97% Spectrum3_000452 HSDB 3338 Tox21_110166_1 Istamina [3H]histamine KBio2_003025 KBioGR_001580 Lopac0_000595 CAS-51-45-6 2631-EP2298734A2 CTK5C2901 2631-EP2305648A1 DSSTox_RID_76884 2631-EP2311831A1 4-(2-Aminoethyl)-1H-imidazole 056H928 714I940 1H-Imidazole-5-ethanamine AC1Q54BV 2-(1H-Imidazol-5-yl)ethylamine ANW-50461 2-imidazol-5-ylethylamine beta-Aminoethylglyoxaline 2631-EP2277566A2 Bio2_000869 2631-EP2286811A1 NCGC00015513-05 NCGC00093371-03 H7125_SIGMA Opera_ID_1772 Histamine, >=97.0% SDCCGMLS-0066601.P001 Histamium Spectrum_000845 IDI1_000308 WLN: T5M CNJ D2Z KB-220202 KBio2_006461 KS-00000XSS MFCD00005210 2631-EP2292280A1 CHEBI:18295 2631-EP2298776A1 2631-EP2305677A1 Eramin 2631-EP2316459A1 (1H-imidazol-4-yl)ethylamine 5-Imidazoleethylamine 1416954-63-6 924364-91-0 2-(1H-imidazol-4-yl)ethan-1-amine AKOS000274386 2-(3H-imidazol-4-yl)ethylamine BBL004932 2631-EP2269989A1 beta-Imidazolyl-4-ethylamine 2631-EP2277569A2 BR-47510 MolPort-002-042-264 NCGC00015513-08 F411C768-A159-4FC0-A195-291A08BB03AA NINDS_000308 Histamine (DCF) RP00535 Histamine, EuropePharmacopoeia (EP) Reference Standard SPBio_000729 HMS1990G19 Theramine Imidazole-4-ethylamine ZINC388081 KBio2_000457 KBio3_001344 L000292 2631-EP2295409A1 CS-4697 2631-EP2305260A1 DSSTox_CID_3125 2631-EP2311802A1 2631-EP2371814A1 .beta.-Aminoethylimidazole 64422-25-9 1avn AC-13185 2-(1H-Imidazol-4-yl)ethylamine AM20100377 2-imidazol-4-yl-Ethylamine BDBM50121205 2631-EP2275420A1 Bio1_001465 2631-EP2280001A1 C-5322 NCGC00015513-03 NCGC00015513-11 GTPL1204 NSC33792 Histamine [USAN] SBI-0050577.P004 Histaminum Spectrum4_000960 HY-B1204 TR-018324 Istamina [Italian] KBio2_003893 KBioSS_000457 LS-75835 CCG-204684 2631-EP2298767A1 D04USC 2631-EP2305652A2 DTXSID4023125 2631-EP2314574A1 4-(2-Aminoethyl)imidazole 1qft AC1Q54BW 2-(3H-Imidazol-4-yl)-ethylamine b-Imidazolyl-4-ethylamine 2-[4-Imidazolyl]ethylamine beta-Aminoethylimidazole 2631-EP2277567A1 bmse000744 2631-EP2287165A2 NCGC00015513-06 Ethylamine, 2-imidazol-4-yl- NCGC00093371-04 Histamin peremin Histamine, analytical standard SMP1_000151 HMS1362G19 ST073926 IDI1_002144 Y9749 KB-237398 KBio3_000853 L-Histamin base MLS000069447 2631-EP2292619A1 2631-EP2300422A1 DB05381 2631-EP2308873A1 Ergamine 2631-EP2316824A1 163355-EP2270002A1 AB00053481_20 2-(1H-Imidazol-4-yl)ethanamine AKOS009158347 2-(4-Imidazolyl)ethanamine BC205752 2631-EP2269990A1 Bio1_000487 2631-EP2277570A2 BSPBio_001117 NCGC00015513-01 NCGC00015513-09 Free histamine NSC 33792 Histamine Base RTR-018324 Histamine, Free Base Spectrum2_000665 HMS3403G19 Tox21_110166 IN1471 [2-(1H-imidazol-4-yl)ethyl]amine KBio2_001325 KBioGR_000457 Lopac-H-7250 C00388 2631-EP2295423A1 CTK1G9684 2631-EP2305640A2 DSSTox_GSID_23125 2631-EP2311803A1 3h-histamine .beta.-Imidazolyl-4-ethylamine 65592-96-3 1H-Imidazole-4-ethanamine AC1L19ZT 2-(1H-imidazol-5-yl)ethanamine AN-24395 2-Imidazol-4-ylethylamine BDBM7966 2631-EP2277565A2 Bio2_000389 2631-EP2281563A1 [ Show all ]
Inchi Key	NTYJJOPFIAHURM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
PubChem CID	774
ChEMBL	CHEMBL90
IUPHAR	1247, 1204
BindingDB	7966, 50121205
DrugBank	DB05381
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
232097	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
232099	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
556387	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448
232100	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
556388	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
232088	Histamine H1 receptor	P35367	HRH1	Homo sapiens (Human)	487
232089	Histamine H1 receptor	P31389	HRH1	Cavia porcellus (Guinea pig)	488
232096	Histamine H1 receptor	P31390	Hrh1	Rattus norvegicus (Rat)	486
232091	Histamine H2 receptor	P47747	HRH2	Cavia porcellus (Guinea pig)	359
232092	Histamine H2 receptor	P25021	HRH2	Homo sapiens (Human)	359
232095	Histamine H2 receptor	P25102	Hrh2	Rattus norvegicus (Rat)	358
232098	Histamine H2 receptor	P97292	Hrh2	Mus musculus (Mouse)	397
232083	Histamine H3 receptor	Q9QYN8	Hrh3	Rattus norvegicus (Rat)	445
232090	Histamine H3 receptor	Q9Y5N1	HRH3	Homo sapiens (Human)	445
232093	Histamine H3 receptor	Q9JI35	HRH3	Cavia porcellus (Guinea pig)	445
232094	Histamine H3 receptor	P58406	Hrh3	Mus musculus (Mouse)	445
232084	Histamine H4 receptor	Q91ZY2	Hrh4	Mus musculus (Mouse)	391
232086	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390
232087	Histamine H4 receptor	Q91ZY1	Hrh4	Rattus norvegicus (Rat)	391
232085	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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